Napoli could lose 3-0 to Juventus as the Coppa Italia holders were unable to travel on Sunday, while Inter Milan and Lazio shared the spoils 1-1, with both sides finishing with 10 men.
Napoli was banned from traveling by local health authorities, after Piotr Zielinski and Eljif Elmas tested positive for COVID-19.
Despite the Azzurri's request to postpone the game, the Serie A league enforced the rule that as long as a team has 13 players available including a goalkeeper, the game can go ahead.
On Sunday night, when Juventus arrived at Allianz Stadium, Napoli remained at home, as per the protocol, Napoli will be handed a 3-0 loss.
In another highly-anticipated fixture between Inter and Lazio, Lautaro Martinez put Inter ahead in the 30th minute, while the Biancocelesti got the game back on level terms 10 minutes after the break with Sergej Milinkovic-Savic's powering header.
The game went into turmoil after that as Ciro Immobile was sent off in the 69th minute for slapping Arturo Vidal after being tripped by the Chilean, while Inter's midfielder Stefano Sensi also saw red in the dying minutes.
AC Milan continued its good forms as the Rossoneri beat Spezia 3-0, including a Rafael Leao brace.
With five players on target, Atalanta enjoyed another convincing victory as the Dea crashed Cagliari 5-2.
Elsewhere, Parma edged Hellas Verona 1-0, Benevento also narrowed past Bologna 1-0.
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