An astronaut treated a frog with care in space. [nasa.gov]
Country: the Soviet Union, United States, Japan
The first frog astronaut was sent into space in March 1961 with the Soviet Vostok 3A flights, along with several mice and guinea pigs.
In 1970, NASA launched a project called the Orbiting Frog Otolith program, which involved sending two bullfrogs into orbit. The frogs were in space from November 9 to 15, during which time researchers collected important neuro-physiological data.
The "Frog in Space" (FRIS) experiment is another example of frogs being used in space experiments. In the experiment, a Japanese cosmonaut took six tree frogs onto the Space Station Mir for eight days in December 1990.