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Iran will discuss its nuclear ambitions with the five permanent members of the UN Security Council plus Germany.
This comes following months of mounting pressure by the US and it's allies over its nuclear program.
China is a key player in this weekend's nuclear summit.
Western countries are anxious to limit Iran's nuclear energy program, fearing it is pursuing military purposes.
Yet Tehran strongly denies this, defending it's right to peaceful nuclear technology.
As a member of the International Atomic Energy Agency and a signatory to the Nuclear Non-Proliferation Treaty or NPT, Iran is entitled to have civil nuclear energy.
Dr. Nursin Atesoglu, Nuclear Expert, said, "Its not a matter of only being a balance of power story anymore. It could be a matter of national pride; it could be a matter of show how you are technologically superior. So there could many explanations as to why you are going nuclear."
Similar attempts to come up with a solution 14 months ago also in Istanbul produced no results.
Yet relations between Beijing and Tehran have developed since then.
For one, China, Iran's largest oil importer, did not sign on to recent US and EU oil sanctions, aimed at pressuring Tehran back to the negotiating table.
As well, China's vetoes of Security Council measure against the Syrian government of Bashar Al Assad have pleased Iran.
Turkey helped negotiate Iran's return to the nuclear conversation yet deteriorating bilateral relations over issues such as Syria, left the venue for talks up in the air. Istanbul was finally confirmed after the P5 members rejected Tehran's alternatives.
"All parties know if comes down to a matter of trust. Tehran says if talks go well here in Istanbul this weekend, a second round of discussion could take place in Baghdad, Iraq later on."