Increasing cell recycling may treat aging-related diseases: study

0 Comment(s)Print E-mail Xinhua, June 14, 2018
Adjust font size:

CHICAGO, June 13 (Xinhua) -- Mice engineered to more quickly recycle their own cells lived longer than their non-engineered siblings, according to a study published on the website of Northwestern University (NU) on Monday.

In a previous study, NU researchers generated mice models of Alzheimer's disease with a single mutation in Beclin 1, causing high rates of autophagy in a variety of tissues, prolonging lifespan and enhancing cognitive function in the Alzheimer's disease mice.

In the current study, they generated normal mice with the Beclin 1 mutation, and found the mice also had prolonged lifespan, as well as delayed aging in the heart and kidney.

"These findings clearly demonstrate that enhancing autophagy is an effective method to promote healthier aging," said CongCong He, NU assistant professor of Cell and Molecular Biology and a co-author of the study. In fact, reinstating higher rates of autophagy may be an effective way to treat aging-related diseases.

"Age-related diseases, such as Alzheimer's disease and type 2 diabetes, reduce not only the quality of life of patients, but also the well-being of family and society. Thus, we're pursuing a way to improve both lifespan and health-span in aged populations," He said.

In the next step, the researchers will search for drugs that can induce autophagy, according to He.

The study has been published in Nature. Enditem

Follow on Twitter and Facebook to join the conversation.
ChinaNews App Download
Print E-mail Bookmark and Share

Go to Forum >>0 Comment(s)

No comments.

Add your comments...

  • User Name Required
  • Your Comment
  • Enter the words you see:   
    Racist, abusive and off-topic comments may be removed by the moderator.
Send your storiesGet more from