Matias Gimenez scored twice as Argentina's Independiente recovered from a goal down to trounce Uruguayan side Boston River 5-1 in the Copa Sudamericana group stage on Tuesday.
Agustin Anello opened the scoring in Montevideo with a seventh-minute strike before goals from Gimenez and Giovanni Millan gave their side the lead at the interval.
Diego Tarzia, Gimenez and Santiago Hidalgo were on target in the second half as Independiente claimed its second win of the tournament.
The team from Avellaneda, south of Buenos Aires, is now second in Group A with six points, two behind leader Guarani. Boston River is fourth, two points further back.
Earlier in the day, Gaston Togni scored with a second-half free-kick as 2020 champion Defensa y Justicia earned a 1-1 draw at Vitoria.
Central defender Edu put the Brazilian side ahead by tapping home from point-blank range after goalkeeper Enrique Bologna fumbled what should have been a routine save from a set piece.
The Argentine outfit equalized just before the hour when Togni curled in a superb free-kick from a tight angle.
Defensa y Justicia remains last in Group B, behind Vitoria on goal difference. Both teams are still searching for their first victories of the tournament.
Elsewhere, Godoy Cruz won 1-0 at Sportivo Luqueno, Guarani drew 2-2 at Nacional Potosi, and Corinthians was held to a 1-1 home draw by America de Cali.
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