BEIJING, June 26 (Xinhua) -- A new study by a Chinese research team exploring how exercise helps the body at a molecular level has discovered that a substance called betaine can mimic the effects of exercise and may support healthy aging.
The study, published in the journal Cell, was jointly conducted by researchers at the Institute of Zoology under the Chinese Academy of Sciences, the China National Center for Bioinformation, and the Xuanwu Hospital under the Capital Medical University.
As the biological basis of life activities, exercise is recognized with well-established health benefits. However, its scientific principles, especially the molecular mechanisms, have not been fully revealed.
With joint efforts over six years, the study team carried out an integrated multi-omics analysis on the molecular-cellular dynamic responses of the human body to acute exercise and long-term regular exercise.
The study revealed for the first time that the kidney is a key response organ to exercise effects. Its endogenous metabolite betaine binds to and inhibits TANK-binding kinase 1 (TBK1), thus reducing inflammation and alleviating the aging process of multiple organs.
The new findings revealed the molecular benefits of exercise and positioned betaine as an exercise mimetic for healthy aging, showed the study. Enditem
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