Officials with Boston's Logan International Airport said they expected airlines to scale back operations during the storm, with the last departure expected at roughly 8:30 p.m. ET.
One traveler worrying that his Friday flight out of Logan could be delayed or canceled was Ruben Raskin, 23, of San Jose, California, who was in the area visiting his girlfriend.
"It kind of reminds me why I moved to San Jose after going to college out here," Raskin said.
Conditions in Boston were bad enough by afternoon that the "Frozen Fenway" winter carnival, featuring sledding and college ice-hockey at the baseball stadium where the Red Sox play, was canceled for Thursday and Friday.
'Dangerous' cold expected
The weather service said the mass of Arctic air would drop temperatures to levels 20 to 30 degrees below normal, with record lows possible on Friday.
"Temperatures are expected to plummet tonight and tomorrow with wind chills dropping as low as 25 degrees below zero (F/-32 C)," said Massachusetts Governor Deval Patrick. "That is a very dangerous set of circumstances."
The low temperature in the contiguous United States on Wednesday was -43 Fahrenheit (-42 Celsius) at Embarrass, Minnesota, the weather service said.
Patrick told non-essential state workers to head home at 3 p.m. ET (2000 GMT) as did his counterparts in neighboring Connecticut. Both encouraged private-sector employers to consider releasing their staff early.
Slippery road conditions made driving a hazard in many storm-hit areas.
In Cleveland, Ohio, Chris Behm spent an hour trying to reach the vocational training center for developmentally disabled people where he works before calling the commute off and urging his 19 employees to stay home.
"It was terrible on all of the roads and there is more weather on its way," Behm said. "It just wasn't worth it to open and possibly kill someone."
While most New York-area schools were open on Thursday, some parents were bracing for the possibility their children would be home on Friday.
"It's tough with these storms because I end up using days off that I don't want to take," said Kristen Carson, who had taken the train into Manhattan from her home in suburban Montclair, New Jersey. "After the holiday, it's really kind of a pinch."
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