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Mental retardation, autism symptoms in mice corrected
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Researchers have successfully corrected key symptoms of mental retardation and autism in mice, which could be a potential treatment for sufferers, according to a study in Neuron magazine on Thursday.

Researchers from the Picower Institute for Learning and Memory at the Massachusetts Institute of Technology (MIT) carried out the tests on mice aimed to correct "Fragile X syndrome," which affects some 100,000 Americans.

"These findings have major therapeutic implications for Fragile X syndrome and autism," said lead author Mark Bear, director of the Institute.

Fragile X syndrome is the most common inherited cause of autism and mental retardation, which can be passed down on the mother's genes and affects one in 4,000 boys.

It is caused by the loss of a gene, known as the "fragile X mental retardation protein" (FMRP), which is believed to act as a brake on synthesizing proteins in the brain.

Researchers sought to prove that the loss of this protein allowed mGluR5 to act unchecked, which stimulates protein synthesis.

The tests proved that cutting the amount of mGluR5 in mice helped to reduce the abnormalities caused by the loss of the other key protein, such as the number of epileptic fits.

"Fragile X is a disorder of excess synaptic connectivity, protein synthesis, memory extinction, body growth, excitability -- and remarkably all these excesses can be reduced by reducing mGluR5," said Bear.

The work indicated that a certain class of drugs could have the same effect with interference with mGluR5, the researcher noted.

But, these drugs are not yet approved, which are expected to go into human safety trials in America next year.

(Agencies via Xinhua December 20, 2007)

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