Taisheng, Qiu Zhifeng, Han Yang, Zhang Hongwei, Wang Zhong,
Liu Zhengyin, Fan Hongwei, Lu Wei, Yu Ying, Wang Huanling,
Zhang Huiyuan, Xie Jing, Zhou Baotong, Ma Xiaojun, Ni Anping,
Wang Aixia, Deng Guohua.
Peking Union Medical
College Hospital, Peking Union Medical College, Chinese Academy
of Medical Sciences, Beijing, China
There has been an outbreak of the severe acute respiratory
syndrome (SARS) worldwide. At present time, SARS is threatening
more and more people in world, especially in Beijing, China.
In order to decrease
mortality maximum, it is necessary to explore pathological
mechanism of SARS. Here we report the severest loss of peripheral
T lymphocytes in 30 cases of patients with SARS.
From March to May 2003, 61 patients were diagnosed as SARS
in Peking Union Medical College (PUMC) Hospital, Chinese Academy
of Medical Sciences & PUMC, after exposure to the try-out
diagnosis criterion made by the Ministry of Public Health,
China. The percentages and absolute numbers of CD4+ and CD8+
T lymphocytes in peripheral blood from 61 cases of patients
with SARS in fever-phase and 56 cases of healthy donors were
detected by immunoflourescent staining. The data is also compared
with other viral infections including HIV, CMV and EBV.
Compared with healthy donors, the subsets
of CD4+ and CD8+ T lymphocytes both have a sharp decrease
in term of relative percentage and absolute count in all cases
of SARS patients. Their peripheral CD4+ and CD8+ T lymphocyte
absolute counts were (（251129/mm3
Such loss of T cells could be much severer than those happen
in patients with other viral infection including HIV, CMV
Severest deficiency of peripheral T cells is key characteristic
in fever-phase of patients with SARS, which might lead to
subsequently large amount of replication of SARS virus and
severe invasion into body. Therefore, application of immunopotentiator
in early stage of infection of SARS virus could be a suitable
strategy. Besides, severe loss of peripheral T cells could
be an impotent biomarker for early diagnosis of SARS.